The purpose of the present study was to investigate the mixed hydrotrophic solid dispersions of Rifampicin (RIF) with hydrotrophic agents like sodium benzoate & citric acid. Mixed hydrotrophic solid dispersions were prepared by using solvent evaporation and hydrotrophy method. The prepared solid dispersions were subjected to particle size analysis, solubility analysis, in vitro dissolution, Fourier Infra Red Spectroscopy, Differential Scanning Calorimetry , X-ray diffraction etc. It was observed that dissolution rate of RIF enhanced to a great extent by solid dispersion technique using sodium benzoate and citric acid as hydrotrophic agents.
Loading....